General Things To Know:
PSN Profiles Trophy Guide
Playstation Trophies Collectibles Guide (including Flashbacks, one thing they don't mention, in Act 4 you can only collect one of Old LA 2040 or Policenauts End Title iPod tunes per playthrough, you have to get the other in another playthrough)
Playstation Trophies Emblem Guide (useful for grinding out Emblems on your Chicken Run especially)
Boss Extreme Non-Lethal Ammo Locations
Vash12349's Naked Run on Boss Extreme with Commentary (sorta Speedrunny, really useful commentary)
Jaguar King's Naked Speedrun on Boss Extreme with no saves
A New Game+ Run on Boss Extreme (This is useful for slow-and-steady tactics, easier ways to take down bosses with New Game + equipment, and for when you find you just can't do frame-perfect speedrun bullshit)
I didn't find this nearly as frustrating as MGS2's. The bosses that fucked me up mostly did so because I hadn't learned the patterns yet or I had made it through a previous encounter with shit damage, whereas some of MGS2's had One Hit Kills and you had to survive for 10ish minutes against them, really only the third part of the Bike Chase is that hard and that's only if you try to do it Naked. Every area felt like if I just figured out the trick, I'd eventually make it through and the checkpoints are generally forgiving (there's a few in Act 2 that are the worst, and one of the tailing areas). You do have to beat the game 8 times to get the Platinum (I'm on #3 right now), but after the Chicken Run and Boss Extreme run, it mostly just takes between two and three hours to beat